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Sunday, April 11, 2021

Spain and Italy to limit AstraZeneca’s Covid jab to over-60s

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Spain and Italy have moved to restrict using the Oxford/AstraZeneca vaccine to folks aged above 60, in shifts that may complicate the international locations’ efforts to step up their vaccination programmes. 

The choices by Madrid and Rome on Wednesday evening got here after the European Medicines Company mentioned earlier within the day that there was a hyperlink between very uncommon blood clots within the mind and the AstraZeneca jab. 

Whereas the EMA, the EU’s prescription drugs regulator, didn’t change its steerage for who ought to take the vaccine, it famous that “thus far, many of the circumstances reported [of blood clots] have occurred in girls underneath 60 years of age inside two weeks of vaccination”.

Belgium individually restricted the AstraZeneca vaccine to these aged 56 or older for at least 4 weeks on Wednesday. Australia moved on Thursday to restrict additional use of the shot in these youthful than 50, with Canberra saying the BioNTech/Pfizer inoculation must be used as an alternative.

France and Germany had additionally beforehand restricted using the shot for the over-55s and over-60s, respectively — trusting that different vaccines, similar to that from BioNTech/Pfizer and a brand new one-shot inoculation from Johnson & Johnson, shall be adequate to make up the lag within the EU’s vaccination programme.

The UK, which is effectively forward of the EU within the vaccine rollout, abruptly changed its guidance over the AstraZeneca vaccine on Wednesday, recommending that individuals aged between 18 and 29 are supplied various jabs. Sweden and Finland permit its use solely within the over-65s, whereas Denmark and Norway have suspended its use till at the very least subsequent week.

Spain’s resolution to make use of the AstraZeneca vaccine just for folks over 60 reverses the nation’s coverage of only a few weeks in the past — till final month it banned using the jab for these over 55.

The brand new stance might make it extra sophisticated to succeed in Spain’s objective — introduced on Tuesday by Prime Minister Pedro Sánchez — of vaccinating 70 per cent of the inhabitants, 33m folks, by the tip of August.

Isabel Díaz Ayuso, head of the Madrid regional authorities, who’s in search of to retain her put up in elections subsequent month, criticised the rule change.

“You possibly can’t continually change the factors,” she mentioned on Thursday. “You possibly can’t change midway via the sport when many individuals are already vaccinated, and when there was ultimately starting to be some readability about which vaccines had been for which teams of individuals.”

Assorted recommendation on the Oxford/AstraZeneca vaccine

  • UK: Underneath-30s must be supplied an alternative choice to the AstraZeneca jab

  • Spain and Italy: Restrict to make use of in these over 60

  • Belgium: Use suspended in folks underneath 56 for the subsequent 4 weeks

  • France and Canada: Restricted to make use of in over-55s

  • Germany: Really useful just for these over 60

  • Sweden and Finland: Used just for over-65s

  • Denmark and Norway: Use suspended in all age teams till at the very least subsequent week

  • Australia: Keep away from additional use on under-50s

At current, 6.4m Spaniards have acquired at the very least one dose of a Covid-19 vaccine. Of these, barely greater than 2m have acquired the AstraZeneca jab, whose use had been accelerating in current weeks. However, in accordance with official figures issued on Wednesday evening, solely 97 folks in your complete nation have acquired a second AstraZeneca dose.

Carolina Darias, Spain’s well being minister, mentioned the nation had not determined whether or not to manage AstraZeneca or one other vaccine to folks underneath 60 who had already acquired a primary shot of the jab.

The Italian well being ministry additionally issued new steerage in a single day saying the AstraZeneca vaccine must be given “preferential use” in these aged 60 and above. The steerage famous the chance of clots, whereas acknowledging that it was low, and including that the chance of extreme Covid-19 will increase with age. 

Italian officers informed a press convention on Wednesday evening that the risk-benefit ratio was nonetheless considerably slanted in the direction of administering the vaccine. Italy had additionally initially restricted using the vaccine to youthful sufferers, eradicating age limits as extra knowledge grew to become obtainable.

Rome’s new tips clarified that those that had already acquired a dose of the AstraZeneca shot ought to full their vaccination with the identical jab, no matter age. 

AstraZeneca on Wednesday acknowledged the findings from the EMA and the UK’s Medicines and Healthcare merchandise Regulatory Company, whereas noting that greater than 200m doses of the shot had been administered worldwide with a comparatively low variety of side-effects. 

The Anglo-Swedish drugmaker mentioned it was working with world authorities to higher perceive the side-effects. The EMA has ordered additional research, to be performed with the Utrecht College and the Erasmus college in Rotterdam.

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